由 K Karikó 著作 · 2004 · 被引用 1167 次 — TLR3 has been shown to respond to double stranded (ds) RNA, a replication intermediary for many viruses. Here we present evidence that heterologous RNA ... ... <看更多>
「tlr3 ligand」的推薦目錄：
tlr3 ligand 在 TLR3 Ligands | Synthetic dsRNA, poly(I:C) | InvivoGen 的相關結果
Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), a PAMP associated with viral infections. The ligand of choice for TLR3 is a synthetic ... ... <看更多>
tlr3 ligand 在 The molecular structure of the Toll-like receptor 3 ligand ... 的相關結果
Recombinant TLR3-ECD Binds dsRNA. TLR3 initiates a signaling cascade in response to dsRNA; poly (I):(C), viral RNA, mRNA, and short interfering ... ... <看更多>
tlr3 ligand 在 TLR3 - an overview | ScienceDirect Topics 的相關結果
The ligand binding sites of TLR3 are separated by approximately 120 Å, which is equivalent to dsRNA of approximately 45 bp in length, the minimal length that ... ... <看更多>
tlr3 ligand 在 Synergy of TLR3 and 7 ligands significantly enhances function ... 的相關結果
Activation of TRIF/MyD88-NF-κB signaling pathway in MoDCs treated with TLR3 and 7 ligands along with inactivated PRRSV antigen. TLRs and MyD88 ... ... <看更多>
tlr3 ligand 在 Structure of Human Toll-like Receptor 3 (TLR3) Ligand 的相關結果
Structure of Human Toll-like Receptor 3 (TLR3) Ligand- binding Domain. Jungwoo Choe1, Matthew S. Kelker1, Ian A. Wilson1. 1Department of Molecular Biology ... ... <看更多>
tlr3 ligand 在 The Response of Tissue Mast Cells to TLR3 Ligand ... - Hindawi 的相關結果
TLR3 ligand -stimulated rPMCs did not degranulate but generated and/or released type I IFNs (IFN-α and IFNβ) as well as proinflammatory lipid ... ... <看更多>
tlr3 ligand 在 Receptor-interacting protein kinase 1 is a key mediator in ... 的相關結果
Toll-like receptor 3 (TLR3) ligand which activates TLR3 signaling induces both cancer cell death and activates anti-tumor immunity. ... <看更多>
tlr3 ligand 在 Tlr3 ligand | Sigma-Aldrich 的相關結果
Nucleic acid-based Toll-like receptor (TLR) ligands are promising adjuvants and immunotherapeutic agents. Combination of TLR ligands potentiates immune ... ... <看更多>
tlr3 ligand 在 Astrocyte Indoleamine 2,3-Dioxygenase Is Induced by the ... 的相關結果
Here we show that the Toll-like receptor 3 (TLR3) ligand poly(I:C) (PIC) induces the expression of IDO in human astrocytes. PIC was less potent ... ... <看更多>
tlr3 ligand 在 TLR3 Ligand Polyinosinic:Polycytidylic Acid Induces IL-17A ... 的相關結果
We investigated the expression of IL-17A and IL-21 in human CD4 + T cells in response to stimulation with the TLR3 ligand ... ... <看更多>
tlr3 ligand 在 Dimerization of Toll-like Receptor 3 (TLR3) Is Required for ... 的相關結果
The extracellular domain of TLR3 dimerizes when it binds dsRNA, ... We conclude that dimerization of TLR3 is essential for ligand binding and that the three ... ... <看更多>
tlr3 ligand 在 TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and ... 的相關結果
Although TLR3 deficiency in mice does not alter outcome after stroke 9, reports have shown that TLR3 activation by ligand polyinosinic– ... ... <看更多>
tlr3 ligand 在 A TLR3 Ligand Reestablishes Chemotherapeutic Responses ... 的相關結果
In synthesis, immunotherapy with the TLR3 ligand pIC fully repairs the immune defect resulting from a deficient ANXA1/FPR1-mediated cancer ... ... <看更多>
tlr3 ligand 在 TLR3 ligand stimulates fully functional ... - ASH Publications 的相關結果
We investigated whether Toll-like receptor ligands (TLR-Ls) can bypass the ... TLR3 ligand stimulates fully functional memory CD8 + T cells in the absence of ... ... <看更多>
tlr3 ligand 在 TLR3 ligands - riboxx RNA Technologies 的相關結果
RIBOXXOL : next generation TLR3 ligands ... Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) implicated in the innate immune response. They are ... ... <看更多>
tlr3 ligand 在 Toll-like Receptor 3 (TLR3) Ligand Exacerbates Pre-existing ... 的相關結果
Toll-like Receptor 3 (TLR3) Ligand Exacerbates Pre-existing Allergic Airway Inflammation in Murine Asthma Model ... RATIONALE: Many clinical investigations have ... ... <看更多>
tlr3 ligand 在 TRAIL, Fas Ligand, TNF and TLR3 in Cancer | SpringerLink 的相關結果
TRAIL, Fas Ligand, TNF and TLR3 in Cancer. Editors; (view affiliations). Olivier Micheau. Provides an up-to-date overview of TNF family signal transduction ... ... <看更多>
tlr3 ligand 在 TLR3 is an endogenous sensor of tissue necrosis during ... 的相關結果
Ligands from dying cells are a source of Toll-like receptor (TLR) activating agents. Although TLR3 is known to respond to RNA from necrotic ... ... <看更多>
tlr3 ligand 在 Ligand dependent restoration of human TLR3 signaling and ... 的相關結果
We investigated the impact of twenty-five cancer-associated p53 mutants on expression of the TLR gene family. Using the TLR3 pathway as proof-of ... ... <看更多>
tlr3 ligand 在 搜索 的相關結果
Toll-like receptor 3 (TLR3) ligand which activates TLR3 signaling induces both cancer cell death and activates anti-tumor immunity. ... <看更多>
tlr3 ligand 在 TLR3 ligand stimulates fully functional ... - Archive ouverte HAL 的相關結果
We investigated whether Toll-like receptor ligands (TLR-Ls) can bypass the requirement for CD4(+) T-cell help in the induction of fully efficient memory ... ... <看更多>
tlr3 ligand 在 The molecular structure of the TLR3 extracellular domain 的相關結果
Given the number and variety of TLR ligands, a fundamental question of innate immunity ... how TLR3 binds its ligand at the molecular level. ... <看更多>
tlr3 ligand 在 (PDF) A Synthetic TLR3 Ligand Mitigates Profibrotic Fibroblast ... 的相關結果
2021年10月13日 — PDF | Activation of TLR3 by exogenous microbial ligands or endogenous injury-associated ligands leads to production of type I IFN. ... <看更多>
tlr3 ligand 在 A TLR3 ligand that exhibits potent inhibition of influenza virus ... 的相關結果
A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an ... ... <看更多>
tlr3 ligand 在 TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and ... 的相關結果
TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia. Yang Li, Xu Lin Xu, Dan Zhao, Lin Na Pan, ... ... <看更多>
tlr3 ligand 在 Recombinant Adenoviral Vector with Encoded TLR3 Ligand ... 的相關結果
Recombinant Adenoviral Vector with Encoded TLR3 Ligand for Protection Against VEE. Award Information. Agency: Department of Health and Human Services. ... <看更多>
tlr3 ligand 在 TLR3-Dependent Activation of TLR2 Endogenous Ligands via ... 的相關結果
TLR3 signaling in inducing endogenous ligands of TLR2 to elicit innate immune responses. Of the various TLR ligands examined, ... ... <看更多>
tlr3 ligand 在 HDM-challenged mice exhibit impaired interferon response to ... 的相關結果
HDM-challenged mice exhibit impaired interferon response to TLR3 ligand in a murine model of viral asthma exacerbation. Hamid Akbarshahi, Mandy Menzel, ... ... <看更多>
tlr3 ligand 在 combination of a tlr3 ligand and a chemotherapy agent which ... 的相關結果
WO2010012965 - COMBINATION OF A TLR3 LIGAND AND A CHEMOTHERAPY AGENT WHICH ACTS ON THE INTRINSIC “APOPTOSIS” PATHWAY IN THE TREATMENT OF ... ... <看更多>
tlr3 ligand 在 LL37 and Cationic Peptides Enhance TLR3 Signaling by Viral ... 的相關結果
Poly(I:C), a synthetic dsRNA analog, is frequently used as a TLR3 ligand [13] and has been co-crystallized with the TLR3 ectodomain [14]. ... <看更多>
tlr3 ligand 在 Intradermal immunisation using the TLR3-ligand Poly (I:C) as ... 的相關結果
Intradermal immunisation using the TLR3-ligand Poly (I:C) as adjuvant induces mucosal antibody responses and protects against genital HSV-2 infection. ... <看更多>
tlr3 ligand 在 Publications - Vaxart Inc. 的相關結果
Oral Administration of an Adenovirus Vector Encoding Both an Avian Influenza A Hemagglutinin and a TLR3 Ligand Induces Antigen Specific Granzyme B and IFN-Γ T ... ... <看更多>
tlr3 ligand 在 RIBOXXIM-TLR3-ligand - RIBOXX Pharmaceuticals 的相關結果
RIBOXXIM. Drug substance : RGIC ® 100 (GMP TLR3 ligand). Riboxxim RGC 2.png. Fig. 1. Interaction of RGIC100 with the TLR3 homodimer. ... <看更多>
tlr3 ligand 在 Adipocyte Fatty Acid–Binding Protein Expression and Lipid ... 的相關結果
Polyinosine: polycytidylic acid (poly I:C), a TLR3 ligand, led to a 9-fold increase. ... Activation of macrophages by TLR ligands such as LPS. ... <看更多>
tlr3 ligand 在 2A0Z: The molecular structure of toll-like receptor 3 ligand ... 的相關結果
The molecular structure of toll-like receptor 3 ligand binding domain. ... Ligand Structure Quality Assessment ... Gene Names: TLR3 ... ... <看更多>
tlr3 ligand 在 SARS-CoV-2 Derived Peptides Potentiate Pro-inflammatory ... 的相關結果
SARS-CoV-2 Derived Peptides Potentiate Pro-inflammatory and Pro-coagulant Responses to the TLR3 Ligand Poly(I:C) in Human Endothelial Cells and Mice · Background ... ... <看更多>
tlr3 ligand 在 (AP22287PU-N) anti CD283 / TLR3 (Ligand bdg. Dom.) - CiteAb 的相關結果
Antibody [AP22287PU-N] anti CD283 / TLR3 (Ligand bdg. Dom.) by OriGene. ... <看更多>
tlr3 ligand 在 類鐸受體 - 科學Online - 國立臺灣大學 的相關結果
... 的配體(ligand) 結合，使成對的受體透過氫鍵及疏水性靠的更緊密，讓受 ... 辨認細菌脂多醣(lipopolysacride) 及鞭毛(flagellin)；而TLR3、7/8及9 ... ... <看更多>
tlr3 ligand 在 A TLR3 Ligand Reestablishes Chemotherapeutic Responses ... 的相關結果
“A TLR3 Ligand Reestablishes Chemotherapeutic Responses in the Context of FPR1 Deficiency.” CANCER DISCOVERY, vol. 11, no. 2, 2021, pp. ... <看更多>
tlr3 ligand 在 TLR3 Ligand PolyI:C Prevents Acute Pancreatitis ... - ReadCube 的相關結果
Toll-like receptor 3 (TLR3) ligand polyI:C is a double-stranded RNA mimic that can be used as an immune stimulant. Our current study indicates that polyI:C ... ... <看更多>
tlr3 ligand 在 Dual Role of TLR3 in Inflammation and Cancer Cell Apoptosis 的相關結果
TLR3 is thus involved in the innate immune response against various viruses ... Like normal cells, human cancer cell lines will respond to TLR3 ligand by ... ... <看更多>
tlr3 ligand 在 The response of tissue mast cells to TLR3 Ligand Poly(I:C ... 的相關結果
TLR3 ligand -stimulated rPMCs did not degranulate but generated and/or released type I IFNs (IFN-αand IFNβ) as well as proinflammatory lipid mediators (cysLTs), ... ... <看更多>
tlr3 ligand 在 Catching the adaptor—WDFY1, a new player in the TLR–TRIF ... 的相關結果
Upon ligand engagement, TLRs elicit an intracellular signaling cascade that ... partial colocalization between WDFY1 and TRIF upon TLR3 ligand engagement. ... <看更多>
tlr3 ligand 在 Recent Advances and Perspectives in Small-molecule TLR ... 的相關結果
However, the natural ligand for TLR3 is double-stranded RNA, while TLR7 and 8 recognize single stranded RNA, and TLR9 recognizes ... ... <看更多>
tlr3 ligand 在 TLR3 agonists | TLR3 ligands | 香港 - Miltenyi Biotec 的相關結果
The natural ligands for TLR3 can be mimicked by TLR3 agonists like polyinosinic-polycytidylic acid (Poly (I:C)), a synthetic RNA oligoribonucleotide (ORN). Poly ... ... <看更多>
tlr3 ligand 在 各種Toll-Like Receptorのリガンド | TLR Ligand | フナコシ 的相關結果
TLR2とヘテロダイマーを形成しているTLR6を活性化する。 NBP2-26219. TLR3, Poly（Ⅰ）/Poly（C）, 二本鎖RNAの合成アナログ, NBP2-25288. ... <看更多>
tlr3 ligand 在 TRAIL, Fas Ligand, TNF and TLR3 in Cancer 的相關結果
All the natural TLR3 ligands identified up to now are dsRNAs coming from pathogens or from endogenous sources. TLR3 has the theoretical ability to play a ... ... <看更多>
tlr3 ligand 在 Toll-like Receptors (TLRs): Novus Biologicals 的相關結果
Learn about Toll-like receptors (TLRs), TLR ligands PAMPs and DAMPs, TLR inhibitors and TLR MyD88 dependent and ... TLR3. PAMPs. Double-stranded RNA. DAMPs. ... <看更多>
tlr3 ligand 在 Oncogene and Cancer: From Bench to Clinic 的相關結果
Like normal cells, human cancer cell lines will respond to TLR3 ligand by secreting inflammatory cytokines, IFN-I and chemokines. ... <看更多>
tlr3 ligand 在 Targeting Toll-like receptors against cancer 的相關結果
The specific ligand for TLR10 has not yet been defined. ... For example, over-expression of TLR2, TLR3 and TLR4 has been detected in majority of colonic ... ... <看更多>
tlr3 ligand 在 The ESC Textbook of Vascular Biology - Google 圖書結果 的相關結果
In a murine model of arterial injury, chronic intraperitoneal administration of the synthetic TLR3 ligand Poly(I:C)—which mimics viral, long, ... ... <看更多>
tlr3 ligand 在 Current Topics in Innate Immunity - 第 16 頁 - Google 圖書結果 的相關結果
Thus only certain iDC (and NK) would undergo the process of pathogeninduced maturation that is induced by given TLR ligand (in this case TLR3 ligand). ... <看更多>
tlr3 ligand 在 TLR & NLR Signaling Pathways : Invivogen 제품 소개 的相關結果
TLR Ligand ; FSL-1, TLR2/6 agonist, Synthetic triacylated lipopeptide (LP) ; Poly(I:C) (HMW), TLR3 agonist, Polyinosinic-polycytidylic acid. Long synthetic analog ... ... <看更多>
tlr3 ligand 在 Target Pattern Recognition in Innate Immunity 的相關結果
Instead, the ligand interaction site is suggested to be formed by a V-shaped valley between dimerized TLR3 ectodomains. The latter view is appealing since ... ... <看更多>
tlr3 ligand 在 自然免疫を発動するTLR3が、1本鎖のRNAも認識することを ... 的相關結果
次に、TLR3が認識した感染細胞由来のRNAを詳しく調べてみた。その結果、ポリオウイルスゲノムの一本鎖RNA(ssRNA)と、その複製中間物のdsRNAからなり、約 ... ... <看更多>
tlr3 ligand 在 Toll and Toll-like receptor signalling in development - Journals ... 的相關結果
Toll/TLRs harbour an N-terminal extracellular ligand-binding domain that ... The expression of both TLR3 and TLR8 in the nervous system is ... ... <看更多>
tlr3 ligand 在 Toll様受容体（トールライクレセプター）の各種リガンド TLR ... 的相關結果
TLR1、TLR2、TLR6はリポペプチドを検出し、TLR3、TLR7、TLR8、TLR9は核酸を認識します。TLR5はフラジェリンを認識し、TLR4は様々なリポ多糖類（LPS） ... ... <看更多>
tlr3 ligand 在 Protein kinase R is an innate immune sensor of proteotoxic ... 的相關結果
PKR was not activated by its canonical ligand, double-stranded RNA but ... downstream of multiple Toll-like receptors (TLRs) (TLR3, TLR5, ... ... <看更多>
tlr3 ligand 在 A TLR/AKT/FoxO3 immune tolerance–like pathway disrupts ... 的相關結果
A distinct sized HA ligand is bioactive and mediates OPC maturation arrest. To define a role for MDa HA depolymerization in myelination ... ... <看更多>
tlr3 ligand 在 Interactions between commensal intestinal bacteria and the ... 的相關結果
NMR structure reveals the molecular basis of ligand binding. Structure (Camb) 11, 791–802 (2003). 124. Zhao, X., Singh, M., Malashkevich, V. N. & Kim, P. S.. ... <看更多>
tlr3 ligand 在 Virtual Screening Approaches towards the Discovery of Toll ... 的相關結果
To handle ligand flexibility, DOCK uses a taxonomic method with an ... Virtual Screening in Toll-Like Receptors: TLR2, TLR3, TLR4, ... ... <看更多>
tlr3 ligand 在 Toll-Like Receptors—Advances in Research and Application: ... 的相關結果
We demonstrate that the TLR3 ligand polyriboinosinic: polyribocytidylic acid (poly(I: C)) induces expression and nuclear translocation of YinYangl where it ... ... <看更多>
tlr3 ligand 在 Toll-like receptorによる病原体認識 - 東京大学医科学研究所 ... 的相關結果
... エンドトキシン)、リポペプチド、ペプチドグリカンなど認識するTLR1、TLR2、TLR4/MD-2、TLR5、TLR6と細胞内に発現し核酸を認識するTLR3、TLR7、TLR8、TLR9に分け ... ... <看更多>
tlr3 ligand 在 Harnessing the Participation of Dendritic Cells in Immunity ... 的相關結果
... have entered clinical phase such as the TLR3 ligand poly ICLC (HiltonolR ) demonstrating tumor regression of advanced facial rhabdomyosarcoma (136), ... ... <看更多>
tlr3 ligand 在 Natural Hosts of SIV: Implication in AIDS - 第 156 頁 - Google 圖書結果 的相關結果
Combination of TLR7/8 or TLR9 ligand-Gag conjugates with additional ... that Gag + TLR3 ligand followed by Gag + TLR7/8 and Gag + TLR9 ligands were most ... ... <看更多>
tlr3 ligand 在 National Institute of Allergy and Infectious Diseases, NIH: ... 的相關結果
Irradiated mast cells also retained responses to TLR ligands. ... Treatment with the TLR3 ligand polyI:C inhibited mast cell adhesion in a dose-dependent ... ... <看更多>
tlr3 ligand 在 Which of the following would be examples of pathogen ... 的相關結果
... that serve as ligands for host pattern recognition molecules such as ... recognized by TLR3 or unmethylated CpG motifs, recognized … ... <看更多>
tlr3 ligand 在 Toll-like Receptor 3 (D10F10) Rabbit mAb#6961 - Cell ... 的相關結果
TLR3 functions as a receptor for double-stranded (ds)RNA typically associated with viral infection (4). It was originally shown to be specifically expressed in ... ... <看更多>
tlr3 ligand 在 TLR3 - Wikipedia 的相關結果
Despite being a glycoprotein, TLR3 crystallises readily – a prerequisite for structural analysis by x-ray crystallography. Ligands[edit]. ... <看更多>